3-D reconstruction of immune cells

A 3-D reconstruction illustrates immune cells (shown in blue) clearing the brain of plaque deposits (in red). (USC Photo/ Marie-Victoire Guillot-Sestier)


Immune system can wipe brain of Alzheimer’s-related plaque

Removing the telltale protein reverses memory loss in mice, USC researchers find

February 06, 2015 Alison Trinidad

New research from scientists at the Keck School of Medicine of USC shows that the body’s immune system may be able to clear the brain of toxic plaque build-up that is the hallmark of Alzheimer’s disease, reversing memory loss and brain cell damage.

The study, which appears in the Feb. 4 edition of the peer-reviewed scientific journal Neuron, identifies a promising avenue for treating a disease that the Alzheimer’s Association projects will affect 16 million Americans over age 65 by 2050.

Rebalancing the immune response

“Alzheimer’s disease is the public health crisis of our time, and effective treatment does not yet exist,” said Terrence Town, professor of physiology and biophysics at the Keck School of Medicine and the study’s senior author.

Our study … may bring new hope for a safe and effective treatment for this devastating illness of the mind.

Terrence Town

“Our study shows that ‘rebalancing’ the immune response to wipe away toxic plaques from the brain may bring new hope for a safe and effective treatment for this devastating illness of the mind.”

Alzheimer’s disease is an irreversible, progressive brain disease that causes problems with memory, thinking and behavior. Affecting more than 5 million Americans today, Alzheimer’s is the most common type of dementia, a general term for loss of memory and other mental abilities.

Brains with Alzheimer’s disease show build-up of a sticky plaque — made of a protein called beta-amyloid — that induces memory loss. When afflicted with Alzheimer’s, the immune system — which typically rids the body of toxic substances — becomes imbalanced and inefficient at clearing those plaques.

Restoring memory loss

In the Neuron study, Town and his team used genetically modified mice to show that blocking a substance called interleukin-10 activates an immune response to clear the brain of the beta-amyloid plaques to restore memory loss and brain cell damage. Alzheimer’s-afflicted mice in which the immune cells were activated behaved more like mice without the disease in various learning and memory tests. Future studies will test the effectiveness of drugs that target interleukin-10 in rats that the scientists have genetically modified to develop Alzheimer’s disease.

USC co-authors include Marie-Victoire Guillot-Sestier, Kevin R. Doty, David Gate, Javier Rodriguez Jr. and Brian P. Leung. The study was supported in part by the National Institutes of Health, American Federation of Aging Research/Ellis Medical Foundation and Zilkha Neurogenetic Institute.

(NIH studies 1F31NS083339-01A1, 5R00AG029726-04, 3R00AG029726-04S1, 1R01NS076794-01)